Protein Details: Glutamate receptor ionotropic; kainate 3

Protein ID

ICDB_Pro_0525

Protein Name

Glutamate receptor ionotropic; kainate 3

Gene Name

Grik3; Glur7

Organism

Rattus norvegicus (Rat)

Length

919 amino acids

AlphaFoldDB

AF-P42264-F1-model_v4.pdb

Function

Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel; gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change; leading to the opening of the cation channel; and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state; characterized by the presence of bound agonist. In association with GRIK2; involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). [Isoform GluR7B]: Ionotropic glutamate receptor that functions as a ligand-gated cation channel; gated by L-glutamate and the glutamatergic agonist kainic acid.

Sequence

MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNAHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRASQMTVNSLQCHRHKPWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP

PDB Structures

3OLZ 3S9E 3U92 3U93 3U94 4E0W 4G8N 4IGR 4MH5 4NWC 4NWD 5NF6 5O4F 6F28 6F29 6JFY 6JFZ 6JMV 6KZM 6L6F 7VM2 8BST 8BSU

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 518; /ligand="L-glutamate"; BINDING 520; /ligand="L-glutamate"; BINDING 525; /ligand="L-glutamate"; BINDING 691; /ligand="L-glutamate"; BINDING 692; /ligand="L-glutamate"; BINDING 739; /ligand="L-glutamate"

Disease

Location

Expressed in the olfactory bulb (at protein level) (PubMed:10023812). Expressed in the deep cortical layers; dentate gyrus; reticular thalamic nucleus; mammillary bodies; pons; and cerebellum of the adult (PubMed:1322826).

DOI ID

10.1016/0014-5793(92)80753-4; 10.1016/s0896-6273(00)80404-3; 10.1016/0896-6273(92)90292-l; 10.1002/(sici)1096-9861(19990308)405:2<233::aid-cne7>3.0.co;2-a; 10.1046/j.1460-9568.2000.01309.x; 10.1016/j.neuron.2008.12.014; 10.1021/pr400783j; 10.1016/j.jmb.2010.10.006; 10.1016/j.jsb.2011.08.014

RefSeq

NP_001106187.1; NP_852038.2